Resveratrol, a phenolic compound found in various plants, including grapes, red wine and resveratrol enriched supplements show promising results in the treatment of cancer, obesity, type 2 diabetes, and cardiovascular diseases. Resveratrol can promote transcription factor nuclear factor-erythroid 2- related factor 2 (Nrf2) activation, increase the expression level of SIRT-1, which is a sirtuin family protein, and reduce mTOR pathway signalling. This compound has anti-inflammatory properties in that it inhibits or antagonizes the nuclear factor-BK (NF-KB) activity, which is a redox-sensitive transcription factor that coordinates the inflammatory response. Inflammation and oxidative stress, which are common features in patients with cardiovascular disease, cancer and neurological disorders and thus SIRT-1 helps in the prevention of such diseases. Resveratrol might also act as an antioxidant and help in anti-aging, and control of cell cycle and apoptosis. Many research studies have suggested that consumption of 250-400ml red wine per day is beneficial in the prevention of many disease conditions especially cardiovascular diseases.
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2022: 6.012
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