Zhang Xichun (1860-1933) was a representative of the Chinese-Western Integration School (zhong xi huitong pai) during the late Qing Dynasty and the early Republic of China. He invented a lot of effective new prescriptions combining Chinese herbs with western drugs. He invented gypsum-aspirin decoction to treat combination of exogenous wind-cold but interior heat. He once had levigated secale coruntum and lactose mixed with Gucong Decoction he formulated, then the mixed decoction was drunk to treat menorrhagia. He used yam, cogongrass rhizome decoction combing aspirin to treat gout. He used Os draconis preparata and concha ostrear, dogwood fruit and potassium bromide to treat nocturnal emission, et al. Zhang Xichun, with open-up and bold mind, inventd gypsum-aspirin decoction to treat diseases for the first time in Chinese medical history and later invented many new prescriptions combining Chinese herbs with western drugs. His creative and aggressive spirits deserve our respect and learning.