A one-pot practical, efficient, and environmentally benign multi-component synthesis of thiazolopyrans using copper nanoparticles in ionic liquid has been developed. The synthesis was achieved via a three component reaction of an aldehyde, cyanoethyl acetate and thiazolidine-2, 4-dione. Further, docking study of thiazolopyrans on human pancreatic lipase related protein 1 receptor co-crystallized using iGEMDock was carried out. The intermolecular hydrogen bonding interaction of the best-fit ligands were found to be associated with His 449, Tyr 473, Cys 289 and Gln 286 amino acid residue at the receptor active site. Compound 4e forms hydrogen bonding with His 449 and Tyr 473 amino acid and gives the minimum energy in the docking result.
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