The effect of pesticide quinalphos on nutritive parameters (protein, carbohydrate and lipid) in the neurosecretory cells (brain, thoracic ganglion and eye stalk) of Spiralothelphusa hydrodroma was determined. The LC50 values were obtained by probit regression line, taking test concentration and corresponding percent mortalities on log value and probit scales respectively. Sublethal studies helped to assess the response of the test organism to stress caused by pesticides. S. hydrodroma were exposed to varying sub-lethal concentrations of quinalphos (24h, 48h, 72h and 96h). Chronic time course studies on the effects of pesticide were conducted by exposing to sublethal safe concentrations for 24 hours. At the end of the treatment period the control and treated crabs were dissected and tissues namely, brain, thoracic ganglion and eye stalk were collected for biochemical studies.