Background: Increasing age is the greater risk factor for Alzheimer’s disease. In older organisms, the brain is less plastic, in part due to a dysregulation of Ca2+ dynamics. The environment of the aged brain, further insulted by the presence of oligomeric amyloid beta, may result in an enhancement of Calcineurin activity sufficient to explicate several negative outcomes observable as decreased neurotransmission, synaptic loss, tau pathology, neuroinflammation, and cell death in Alzheimer’s affected brain. Therefore, it is prudent to consider the possibility of Calcineurin inhibition as a pharmacological target in the development of novel Alzheimer’s disease therapies.
Method: The present insilico study makes a comparative analysis of different immunosuppressant against Calcineurin which acts as molecular switch in the AD pathology. This study has been conducted by using different bioinformatics tools and software as Lipinski filter online tool, discovery studio 2.0 and patch dock tool.
Result: By docking study it has been observed that among cyclosporine, pimercolimus, tacrolimus and voclosporin; voclosporin shows higher affinity to the target molecule Calcineurin with higher patch dock score.
Conclusion: Voclosporin may present as possible ligand for the targeted protein calcineurin, for suppression of neuroinflammation which is the prominent causative agent for progression of Alzheimer’s disease.
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2022: 6.012
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