Leea macrophylla herb is known to possess potent anti-inflammatory activity. In the present study the ethanolic extract of Leea macrophylla significantly inhibited the haemolysis of erythrocytes and heat induced protein denaturation in vitro models. Thus it can be postulated that the anti-inflammatory activity of Leea macrophylla could be due to its membrane stabilizing action and inhibition of protein denaturation.