Introduction: Approximately 40% Type 2 diabetes and 30 % Type 1 diabetes suffer from kidney failure. Uncontrolled diabetes were more prone to end stage renal disease which required kidney transplantation, haemodialysis or peritoneal dialysis adds psychological & financial burden. Early kidney injury can be prevented by evaluating gene pressions of kidney injury molecule-1 in Type 2 diabetes with microalbuminuria. Methodology: It is cross sectional study includes 241 subjects (118 male, 123 women, between age 30-70 years). Subjects were recruited after screening for Type 2 diabetes by easurement of blood glucose (FBS & PP), HbA1c and microalbumin in urine. Subjects with chronic clinical conditions and uncontrolled blood glucose level were excluded from the study. Equal numbers of healthy volunteers were enrolled in control group and expressions of kidney injury molecule-1 measured by rt-PCR. Results: In study groups all renal parameters found within normal range except albumin creatinine ratio (p <.012) & e-glomerular filtration rate (p <.00). Kidney injury molecule-1 showed high degree of ignificance (p <.00). Conclusion: Biochemical renal parameters are not enough to speculate nephropathy. Early detection of gene expressions of kidney injury molecule-1 may suggests the status of kidney functions & help to prevent progression of diabetic nephropathy.
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