Over the Counter (OTC) drugs are medicines which are sold directly to a consumer without any prescription from the pharmacy. Trend of using OTC drugs/self-medication is high in India. Self medication increases the chances of illicit use of drug and can lead to drug dependency. Due to uncontrolled use of OTC drugs, signs and symptoms of underlying diseases are suppressed hence incidence of delayed diagnosis, complications, treatment failure and drug resistance are increasing. Use of Over the counter drug as well as self – medication is a very common problem in India. Dental students are of no exception at this malpractice. Hence the objective of this study to assess the knowledge and practices of OTC drugs among the dental students.