Toxicity of silk dye waste on lung of swiss albino male mice mus musculus and its mitigation by using moringa oleifera leaf extract

The object of this histopathological study was to investigate critical lung toxicity caused by silk dye waste effluent and amelioration by using of medicinal plant Moringa oleifera leaf extract.Five sets of animals i.e. Group I (Control), Group II (fed with 50% silk dye), Group III (fed with 100% silk dye), Group IV (mice fed with 50% dye treated with M. oleifera leaves powder), Group V (mice fed with 100% dye treated with M. oleifera leaves powder) have been taken for experiment. The dose of silk dye was 2ml/day to both groups II and III and M. oleifera leaf is given as per the standard dose (300mg/kg b.w) to both animals of group IV and V. The histological examinations of this study revealed a damage and degeneration in the lung tissues of the silk dye treated animals. Moringa oleifera administration to silk dye treated mice showed reduction in the tissue damage and amelioration of restored the normal distribution of elastic fibres in lung. These results, along with previous observation, suggest that M. oleifera may be useful in lung tissues injury that is a result of silk dye waste effluent toxicity.