In-vitro dissolution enhancement of nimesulide using hp-β-cd by kneading method

The purpose of the current investigation was to enhance in vitro dissolution rate of nimesulide using HP-β-CD. Nimesulide is widely used as antiarthritics, antipyretic and spondylitis. Nimesulide is BCS class II drug having low solubility, low bioavaibility and low dissolution rate. For improving solubility and enhancement of dissolution rate of drug derivative of cyclodextrin was used to prepare complex. Here, kneading method was used for formulation. Different batch of different concentration of HP-β-CD was prepared and we get batch B3 having enhanced dissolution rate of Nimesulide compare to all other batches.