Introduction: Based on the results of ethno medical on the one hand and the other hand the resistance of some medico-veterinary parasite and candida strains as well as the unavailability and toxicity of synthetic anthelminthics and antifungal on humans, animals have pushed scientists to turn to plants with anthelminthic and antifungal properties. Hence, the aim of this work was to contribute to the fight against infectious and parasitic diseases. Materials and Methods: The anthelmintic activity of polyphenol-rich fraction of stem bark from Lannea acida a. Rich., has been evaluated using earthworms as parasites. Various concentrations of the formulation (25 mg/ml, 50 mg/ml and 100 mg/ml) were tested which involved determination of paralysis time and death time of the worm. Albendazole (25 mg/ml) was used as the reference standard. The antifungal activity was investigated using the microplate dilution method. Results: The polyphenol-rch fractions of stem bark from lannea acida was showed the anthelmintic activity. The polyphenol-rch fractions at a concentration of 100mg/ml showed paralysis at 2.82 minutes and death of earth worm at 26.91 minutes. As for the antifungal activity, result varied according to microorganism. Conclusions: These findings obtained from this work confirmed the using of Lannea acida to treat intestinal worm infections and antifungal activity. Further studies are needed to determine the chemical identity of the bioactive compounds responsible for the observed anthelmintic and antifungal activities.
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2022: 6.012
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