Introduction: Antibiotic resistance in Uropathogens is a worldwide problem. With the evolution and modernisation, medical practice in India is facing strong challenges by development of drug resistance in bacteria. With no development of newer antibiotics, physicians are evaluating whether older antimicrobials are again becoming useful. Thus, Fosfomycin and Nitrofurantoin are gaining attention as they are showing good response in treatment of urinary tract infection.
Aims: To evaluate the various Uropathogens causing UTI & their invitro susceptibility to Nitrofurantoin & Fosfomycin in patients attending hospital. Materials and Methods: This prospective study was conducted in Department of microbiology, Narayan medical college & hospital, Sasaram from November 2018 to June 2019. A total of 1110 samples were processed, 271 sample showed pure growth of various isolate. Antibiotic sensitivity testing was done by Kirby-Bauer disc diffusion testing and interpretation was done according to
the CLSI guidelines 2018 (M100-S23).
Results: 271(24.4%) cases showed positive growth in 1110 urine samples. The predominant isolates were E. coli (no=142), klebsiella spp. (no=31), p. aeruginosa (No=32) among gram negative bacteria, staphylococcus spp. (no 40) and Entrococcus spp. (no =15) among gram positive bacteria.
Conclusion: In the era of increasing drug resistance older antibiotics like Fosfomycin & Nitrofurantoin can prove to be a good first line empirical option to treat UTI.
Impact Factor
2022: 6.012
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