Thiosemicarbazone is a well known Schiff based ligand with versatile bonding modes and biological activities. Upon coordination to metal, thiosemicarbazones and its complexes have shown remarkable progress in the development of drugs for medical conditions owing to their antibacterial, antifungal, antiviral as well as antitumor properties. In this review article, the recent information about biological studies conducted on thiosemicarbazones and its complexes is summarized. Thiosemicarbazone complexes with transition metals hold several advantages over metal complexes because of their better acceptability and low toxicity in biological process. They have shown better performance than available therapeutic drugs like that of the antitumor drug cis-platin. This review will also provide latest updates on current advances in medical use of thiosemicarbazone complexes.
Impact Factor
2022: 6.012
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