Uv-spectrophotometric analytical method development and validation for determination of telmisartan in pharmaceutical drug and drug product (tablet dosage form)

An easy, simple, specific, speedy, precise and accurate UV Spectrophotometric method have been developed and validated for content determination of Telmisartan. Drug Telmisartan demonstrated the absorption maxima in at 296.5 nm and found was linear for a range of 5 µg/ml –25 µg/ml with correlation coefficient of 0.9994. The limit of detection (LOD) of Telmisartan was found to be 1.3µg/ml and the limit of quantification (LOQ) of Telmisartan was found to be 4.5µg/ml. The analytical method validation of the above proposed method was performed by carrying out precision and accuracy studies. The Accuracy percentage recovery on three different levels i.e. 80%, 100% and 120% was found to be 79.6%, 100.7% and 117.9% respectively. The proposed analytical method demonstrated good Intra precision (Repeatability) with relative standard deviation 0.896% and Inter precision with relative standard deviation is 0.671% which is less than 2. The proposed analytical method was validated for the test parameter Specificity, Precision, Linearity and range, Ruggedness, Accuracy and recovery. Hence proposed analytical method for content determination of Telmisartan formulation drug in tablet dosage forms by UV spectrophotometer in pharmaceutical found easy, simple, accurate, precise and reproducible, economical and can be applied for the everyday quality control analysis.