A Precise, accurate, rapid, simple, and sensitive spectrophotometric procedures for the determination of desloratadine (DSL) in pure sample and in dosage forms has been developed. The procedures are based on oxidation of the drug by ceric ammonium sulphate and/or N-bromosuccinimide in acidic medium and determination of the excess oxidant by measuring the decrease in absorbance for two different dyes; amaranth (AM) and methyl red (MR), at a suitable λmax. Regression analysis of Beer’s plots showed good correlation in the concentration ranges 2.0-20 µg mL-1. The apparent molar absorbtivity, Sandell sensitivity, detection and quantitation limits were calculated. For more accurate results, Ringbom optimum concentration ranges were 4.0-16 µg mL-1. The validity of the proposed procedure was tested by analyzing in bulk and in dosage forms containing DSL. Statistical analysis of the results reflects that the proposed methods are precise, accurate and easily applicable for the determination of DSL in pure form and in pharmaceutical dosage forms compared with the Official method.
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