Urinary γ - glutamyl transferase and urine protein - to- creatinine ratio estimation as prognostic renal markers in pyometra affected dogs

Twenty four cases of pyometra (confirmed by ultrasonography) were classified into three groups I, II and III, treated under different treatment regimens. The animals were presented at the university veterinary hospitals of Kerala Veterinary and Animal Sciences University, Pookode, Wayanad. Detailed clinico-gynaecological and ultrasonographic examination of the reproductive tract, haemato-biochemical tests and urine samples were collected on the day of admission (day 0) and subsequently on day 5,10 and 20 for the estimation of haemato-biochemical parameters and kidney function for case diagnosis and prognostic evaluation. The dogs were subjected to urine catheterization for examining the biochemical parameters such as Urine protein – to - creatinine (UPCR) ratio and Urinary γ - glutamyl transferase (UGGT) estimation for prognostic evaluation. Urine protein – to – creatinine ratio values ranged from 0.05 ± 0.01 to 0.71 ± 0.36 and statistically no significant (P>0.05) difference was noticed between the three groups on different days of observation. Urinary γ - glutamyl transferase estimation had no statistically significant difference observed between the groups (P>0.05) on different days of observation. However, a highly significant (P<0.01) decrease in the values ranging from 31.25 ± 0.49 to 12.75 ± 0.86 (IU/L) observed within all the three groups I, II and III from day 0 to day 20.