Delusional Parasitosis is a psychiatry disorder the exact aetiology was unknown but some imaging and clinical investigational studies shows abnormalities in the Dopamine and Serotonin present in the Central nervous system. Along with some of the other Diseases may induces the Delusional Parasitosis like Schizophrenia, Depression, Parkinsonism and endocrine disorders like Thyroid, some of the drugs also may induce like Cocaine and narcotics along with Drugs like anti-Parkinson agents, stimulants, antidepressants, antihypertensives, antiepileptics may also Induce the Delusional Parasitosis. The exact prevalence of delusions of Parasitosis is unknown and the literature includes one report of suicide in a 40-year-old man with delusions of parasitosis. It can be treated by using the anti psychotics especially in atypical antipsychotics like Aripirazole, Olanzepine and Respiridone.