Background: The aim of the present study is to assess the total Phenolics, total flavanoid, antioxidant and antimicrobial activities of different extracts of Clerodendrum serratum L.
Methods: Subsequent extractions were done by using socklet apparatus with solvents with increasing polarity petroleum ether, chloroform, methanol and water for estimation of phenols, flavanoids antioxidant and antimicrobial activity.
Result: Methanolic extract has the highest amount of total phenolic (7.95±0.09 mg GAE/g) total flavanoid (39.11±0.32 µg QE/g). The greatest scavenging capacity was found in methanolic extract (IC50=15.96 µg/mL), the total antioxidant capacity was high in the methanolic extract (IC50=19.86 µg/mL). S. aurenus, M. lutens, E. faecium, L. monocytogenes, S. typi showed the highest zone of inhibition in methanolic extract where as E. coli and P. aeruginosa in water extract.
Conclusion: selective extraction of bioactive molecules from the natural sources with appropriate solvent can provide compounds with high biological activity.
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