Therapeutic efficacy of certolizumab pegol in the treatment of rheumatoid arthritis associated with eritema elevatum diutinum: case report and literature review

Erythema Elevatum Diutinum (EED) is a rare and chronic form of vasculitis manifested as skin lesions predominantly. EED has been described in association with hematological malignancies, infections and rheumatological diseases. We report the case of a patient with rheumatoid arthritis (RA) who presents with skin manifestation in hand and elbows. Skin biopsy confirmed the diagnosis of EED and treatment with Certolizumab Pegol (Cimzia ) resulted in improvement of skin lesions. Since EED is rarely reported in association with RA as neither exists literature describing the use of anti-TNF monotherapy for EED, we present the therapeutic efficacy of Certolixumab Pegol (Cimzia ) in the treatment of EED in a patient with rheumatoid arthritis.