Natural toxins are present in numerous types of plants and these are ingested as food and when consumed in large quantity are not cook properly leads to food poisoning. Plant toxins are generally the metabolites produce through plants to protect themselves against different threats like insects, predators and micro organisms (bacteria, fungi, viruses etc). These can also be found in food plants because of natural choice as well as new reproduction methods which enhance these defensive mechanism. The plant part which may cause toxic effects includes roots, tuber, stem, fruits, buds and foliage. This present review focuses on describing those toxic effects of plants in humans.