Isentropic compressibility’s for the binary mixtures of water with methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, and 2-butanol have been computed from the experimentally measured densities and sound speeds at 298.15 K over the entire composition range. All the systems studied exhibit contraction on mixing. The results have been discussed in terms of the specific interactions between the component molecules of the binary mixtures.