Study of serum uric acid level in metabolic syndrome

The metabolic syndrome is a global public health problem. Metabolic syndrome is associated with increased insulin levels due to insulin resistance. Hyperinsulinemia reduces the renal excretion of uric acid. Hyperinsulinemia reduces the renalexcretion of uric acid. Hyperuricemia may precede the onset of diabetes, hypertension, coronary artery disease, and gout in such individuals. Objectives of the study was to -
1. To estimate the uric acid levels in metabolic syndrome.
2. To study the relationship between serum uric acid levels with different components of metabolic syndrome.
Materials and Methods: The present study is a cross sectional observational study undertaken in rajarajeshwari medical college and hospital Bangalore including 60 individuals 30-60 years of age with features of metabolic syndrome who underwent clinical, anthropometric and biochemical evaluation
Results: In this study hyperuricemia was found to be more prevalent in men than women. This study also shows serum uric acid is markedly associated with metabolic syndrome, elevated waist circumference and high triglyceride were statistically significantly associated with higher uric acid concentration.
Conclusion: Considering the worldwide increase in the incidence of metabolic syndrome and the potential link to hyperuricemia, more emphasis should be put on the evolving morbidity prevalence of hyperuricemia in our country.