Background: Vitamin D is an important secosteroid hormone with pleiotropic effects. While its role in the regulation of calcium and bone homeostasis is well established, recently there is increasing recognition that Vitamin D has immune modulatory, anti-inflammatory and anti-fibrotic properties and plays an important role in the regulation of cell proliferation and differentiation. Liver is a major organ participating in activation of Vitamin D to 25 (OH) Vitamin D. In cirrhosis synthesis of 25 hydroxy Vitamin D is reduced as consequence the circulating active form 1-25(OH)2 vitamin D3 is reduced. This in turn affects the prognosis of liver disease of any etiology. Aim of The Study: To study the correlation of severity with serum 1-25(OH)2 Vitamin D3 levels in patients with cirrhosis of liver. Methodology: To study the correlation of severity with serum 1-25 (OH)2 vitamin D3 levels in patients with cirrhosis of liver. The levels of Serum vitamin D3 levels was assessed by chemiluminescence method. The relations of vitamin D3 deficiency to the severity of liver impairment were determined by Child Turcott Pugh score (CTP) and model for end stage liver disease (MELD) score. Results: In this study the mean serum Vitamin D levels was 13.46mg/dl. Thirty one (62%) patients had insufficiency (20-30ng/ml) and 19 (38%) had deficiency (<20ng/ml). Thirty eight (76%) patients belonged to child C category, Ten (20%) to child B and 2 (4%) to child A. The mean MELD score was 17.84. Conclusion: The severity of Vitamin D deficiency correlated with the severity of liver disease as evidenced by the correlation between the child status and MELD scores. The association of vitamin D with liver cirrhosis shows great potential for clinical application. The relation between vitamin D deficiency and the degree of liver function, degree of fibrosis and infectious complications could support its use as a prognostic index and diagnostic tool.
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