Chronic liver disease is a disorder that presents with progressive destruction of liver tissue. liver has a central role in body metabolism and performs some very important metabolic functions. it has a key role in lipid metabolism including synthesis, storage, break down as well as lipid disorders. Lipids are an important component of biological membranes and have other functions like steroid hormone synthesis etc. the present study was planned to evaluate the various lipid profile components in patients diagnosed with chronic liver disease. Fifty patients diagnosed with chronic liver disease were enrolled for the study. Fifty age and gender matched individuals constituted the control group. For all subjects thus enrolled, fasting blood samples were collected and evaluated for serum lipid profile. Results obtained were later subjected to statistical analysis. It was observed that CLD patients had lower concentration of lipid components as compared to healthy control group. The study recommends regular screening of lipid profile and to identify more biochemical markers for evaluation of the severity of disease.