Bleeding in early pregnancy is a common. It has been linked with adverse obstetric outcome. Inadequate angiogenesis, inflammation of chorionic tissue, defective placentation and mechanical separation of the developing placenta are some of the mechanisms described. Traditionally progesterone has been prescribed in such cases to augment the luteal support. Post IVF (in vitro fertilization) pregnancies are usually on progesterone support in early pregnancy. Tranexamic acid is a hemostatic agent which binds lysine sites on plasminogen and act as competitive inhibitor of plasminogen activation thereby preventing fibrin degradation. Its safety and effectiveness have been established in various clinical scenarios. Use of Tranexamic acid in post IVF pregnancies with threatened abortion arrested the bleeding rapidly and found to be safe and effective. Study can be a basis for other studies with more representative sample and better study design.
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2022: 6.012
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