Background: Organophosphorus compound poisoning is the most common poisonings in India because of easy availability often requiring Intensive care and ventilator support. Clinical research has indicated that respiratory failure is the most important cause of death due to organophosphorus poisoning. It results in respiratory muscle weakness, pulmonary oedema, respiratory depression, increased secretions and bronchospasm. These complications and death can be prevented by proper assessment and timely institution of ventilator support. Aim of The Study: To compare PSS with APACHE-II score in predicting severity and clinical outcome in patients of organophosphrous poisoning. Methodology: 50 patients admitted with a history of organophosphorus poisoning at Osmania general hospital, Hyderabad were taken for study after considering the inclusion and exclusion criteria. Detailed history, confirmation of poisoning and all relevant blood investigations are done. The severity and clinical outcomes in OP poisoning is graded by PSS (poison severity score) and APACHE II scoring systems. Results: Out of 50 patients 39(78%) patients were males, 11(22%) patients were females. Mortality in age group < 45yrs is 31.7%, Mortality in age group 45-65 yrs is 50%, Mortality in age group >65 yrs is 100%. The minimum APACHE II score obtained in our study is 0 and the maximum score is 35.No patient survived with APACHE II score of more than 20. In this study PSS was graded to all 50 patients, of which 2 patients fall in Grade 0,of which all are survived, 17 patients fall in grade 1of which 16 patients are survived and one patient died,21 patients fall in grade 2 of which 12 patients survived,9 patients died. Conclusion: There is a significant linear correlation between APACHE II scores and the PSS scores on marking correlation graph. As the PSS depends mainly on clinical features of patient, there can be differences in grading of PSS from physician to physician.
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