A study of bone marrow abnormalities in hiv positive patients with peripheral hematological abnormalities and its correlation with cd4 count

Background: We are beginning to learn various clinical manifestations and abnormalities in patients with HIV disease in India. There is a possibility that the manifestations in Indian patients may not be the same as reported from other countries like USA and Africa. Hence, it is imperative to methodically observe and follow clinical and laboratory aberrations in such patients in order to improve our diagnostic and therapeutic skills pertinent to HIV/AIDS. Here, we aimed at studying the bone marrow abnormalities in patients with HIV disease and to investigate their association with peripheral blood abnormalities and CD4 count. Aim of the Study: To correlate the association of Bone marrow abnormalities and CD4 count. Material & Methods: This study was conducted in Department of General Medicine, Osmania General Hospital, Hyderabad, by applying the inclusion and exclusion criteria, we selected 50 patients for our study among them. Results: Out of 59 patients 14(28%) were grouped as non AIDS and 36(72%) as AIDS(NACO criteria). Peripheral blood and bone marrow examination was done in 50 patients with either anemia, leucopenia or thrombocytopenia or in their combination. Conclusion: Peripheral and bone marrow abnormalities are common in HIV related disease and has got significant impact on clinical outcomes and quality of life (QOL). HIV infection affected the highly productive a 21-40 years of age (74%) and predominantly males (80%) in the present study.