Background: The purpose of the study was to assess the effectiveness of structured teaching programme regarding Kangaroo Mother Care in terms of knowledge among the pregnant women attending Mamta clinic at PHC, Karamsad. The literature review revealed about the importance of KMC. Method: A quasi experimental study was performed on pregnant women using structured knowledge questionnaire interview. Result: The pre-test knowledge mean score and SD of samples was 11.6 (39%) & 3.9. The post-test knowledge mean score and SD was 22.18(80%) & 3.2. The data further indicates that the post-test mean percentage scores in content were higher than the pre-test mean percentage. The percentage gain was 41% so the investigator concluded that there was significance increases in the mean post-test knowledge score as compared to mean pre-test knowledge score. The Calculated value of chi square for education was 7.98 which was less than tabulated value of chi square (15.51) so it was not statistically significant at 0.05 level of significance. It shows that knowledge level of samples regarding Kangaroo Mother Care does not make any difference by their education. The calculated value of chi square for no. of children was 5.02 which was less than tabulated value of chi square was 9.49. So it was not statistically significant at 0.05 level of significance. It proved that knowledge level of samples regarding Kangaroo Mother Care does not make any difference by their No. of children. Conclusion: Investigator concluded that women attending Mamta Clinic gained significant increased in knowledge shows that the Structured Teaching Programme was effective. There was no significant association between various demographic variables, such as Education and No of children. Hence it is concluded that Structured Teaching Program was effective in improving the knowledge of the pregnant women attending Mamta clinic at PHC Karamsad.