Tuberculosis is a preventable and curable disease like other disease. The disease primarily affects the lungs and causes pulmonary tuberculosis. The problem of TB is acute in the developing countries which accounts for more than three fourth of the cases in the world and where the majority of cases are never diagnosed at all, less get correctly treated. Multi Drug Resistance Tuberculosis (MDR-TB) is the uprising issue in controlling Tuberculosis. It is a condition which enables to disease causing organism Mycobacterium Tuberculosis to resist the anti- tuberculosis drugs. Reliable data on the epidemiology of MDR-TB are lacking from India. Though the problem of drug resistance was observed in the early studies from India resistance to both isoniazid and rifampicin has been a recent phenomenon. In certain areas, currently available program approach may not be adequate and innovative approaches such as DOTS-plus may have to be employed to effectively control MDR-TB.