Etoposide is a cytotoxic anticancer drug which is used as a form of chemotherapy for cancers. Inclusion complexes were prepared between Etoposide and α- cyclodextrin in solid and solution state. The obtained inclusion complexes were characterized using UV-VIS, Fluorescence FT-IR Spectroscopic Studies and SEM. The results obtained confirm the inclusion of etoposide in the cyclodextrin cavity.