In this study, dexlansopraxole was determined by stability indicating RP-HPLC analysis. The mobile phase was eluted with a Phenomenex C18 column (150 × 4.6 mm, 5 μm). 0.1M NaH2PO4: methanol (55:45) was used as mobile phase. The flow rate was 1.0 ml/min and eluents were detected at 270 nm at column temperature of 30 °C. Dexlansopraxole was subjected to stress conditions like acid, base, oxidative, thermal and photolytic. The degradants produced were well resolved from dexlansopraxole with different retention time values. The method linearity (R2 = 0.9998) is in the range of 25 - 200 μg/ml. The precision (relative standard deviation values are less than 0.5%) and accuracy (percent recovery values are nearer to 100%) results were satisfactory. The proposed method has high throughput as short run time (5 min) was short. The proposed method was successfully applied for the determination of dexlansopraxole in capsule dosage forms with acceptable results.
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2022: 6.012
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