Objective: To study the significance of SerumProcalcitonin (PCT) in determining the prognosis in patients with systemic inflammatory response syndrome (SIRS)/ sepsis.
Introduction: Sepsis is defined as SIRS in the presence of an underlying infectious process, and is associated with high rates of morbidity and mortality particularly when initial therapy is delayed. PCT is currently the most studied infection biomarker and its blood levels seem to mirror the severity of illness and outcome. PCT may help in discriminating infections and can have prognostic value.
Methods: Total numbers of 200 cases of SIRS/ sepsis admitted in medical ICUs were included in the study. PCT levels were compared in moderate SIRS, severe sepsis and septic shock. PCT values andoutcome was analyzed.
Results: Out of total 200 cases, 182 had PCT value ≥0.5 ng/ml whereas 18 had PCT value of <0.5 ng/ml. As the PCT value increases mortality increases. In the PCT levels <0.5 ng/ml and ≥0.5-<2 ng/ml, mortality was 6.4% and 18.3% which was less as compared to patients who were discharged in satisfactory condition being 12.1% and 28.6% respectively.
Conclusion: PCT as a biological marker appears to have a significant value in determining the prognosis of the patient with SIRS/Sepsis
Impact Factor
2022: 6.012
This work is licensed under a