Purpose: To analyse the association of oxidative stress (GGT activity) and inflammatory response (Sialic acid levels) with glycemic control (HbA1C) in patients with type 2 diabetes mellitus.
Methods: This non-Interventional, cross-sectional study comprised of 60 study subjects with 30 type 2 diabetes patients (the case group) and 30 healthy individuals (control group). From the venous blood, serum GGT was measured spectrophotometrically using commercially available kits. Total sialic acid was measured by using diphenylamine method and glycated haemoglobin (HbA1C) was measured using ion-exchange resin method on a spectrophotometer.
Results: The results showed a significant increase in the MDA levels in the elderly population (1.851 ± 0.583 µM/L) in comparison with the young adult population (0.963 ± 0.302 µM/L). There was also a significant reduction in the TAC the elderly, individuals (1.189 ± 0.411 µM/L) as compared to younger adults (1.342 ±0. 575 µM/L; p<0.001). But we did not find any significant correlation between the TAC and MDA levels in the study population.
Conclusion: In conclusion, the present study suggests that serum GGT and Sialic acid concentration is significantly increased in type 2 diabetes mellitus as compared to healthy control. There is a significant positive correlation between GGT and HbA1C. All these findings suggest a link between oxidative stress, inflammation and glycemic control in patients with type 2 diabetes mellitus.
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