Diabetes Mellitus is a disease of metabolic dysregulation, affecting millions of people worldwide. Recent studies have emphasized the role of serum ferritin in insulin resistance. The relationship between iron metabolism and type 2 diabetes mellitus is bi-directional. Iron affects glucose metabolism and glucose metabolism impinges on several iron metabolic processes. The aim of this study is to establish an association between serum ferritin, FBS and HbA1c in type 2 diabetes mellitus and to evaluate the role of serum ferritin on glycemic status.
A case control study was conducted on 60 diabetic patients and 60 controls, aging between 30-65 years, admitted in the Department of Medicine, GMC, Jammu. The participants were categorized into three distinct groups. Estimation of blood glucose, HbA1C, and serum ferritin levels was performed on all subjects and controls.
Serum ferritin increased significantly in diabetes mellitus patients with high HbA1c or with complications, ie upto 293.9 ± 20.6 ng/ml from 168.5 ± 11.8 ng/ml, for those without complications and 100.6 ± 7.0 ng/ml amongst healthy controls. The present study showed positive correlation between increasing serum ferritin amongst Type 2 diabetics with complications, signalling towards an alarming development of hemochromatosis in a long standing diabetic patient.
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