Self emulsifying drug delivery systems (SEDDS) are one of the novel approaches to increase the solubility and permeability of drugs belonging mainly to BCS class II (low solubility and high permeability) and IV (low solubility and low permeability). SEDDS are isotropic mixtures of lipids, surfactants and co-surfactants which are selected based on the solubility of the lipophilic drug in individual excipients. Pre-concentrate of SEDDS form oil/water emulsion in gastro-intestinal tract upon mild agitation. Thermodynamically stable micro emulsions can be achieved as a fixed ratio of surfactant and co-surfactant is used which are selected based on the pseudo ternary phase diagrams. Conversion of liquid SEDDS into solid dosage forms of SEDDS like tablets, capsules or pellets makes them more patient complaint and easy to administer. This approach increases the bioavailability of the lipophilic drugs by enhancing their solubility.
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2022: 6.012
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