Depression has always been a disorder of focus of attention of researchers due to its importance in terms of its prevalence, suffering, morbidity as well as economic burden. One year prevalence has been estimated to be 5.8 % for men, and 9.5 % for women.1 It has been mentioned as the second leading cause of disability adjusted life years among the affected.2 The available therapeutic options are not up to the expectations of the medical community. In classical textbooks of Ayurveda, clinical features regarding Unmada are explained and many of these symptoms can be compared with that of depression. Many conceptual as well as clinical studies have been conducted in the postgraduate department of Psychiatry here. This attempt is being done to review the studies conducted in order to advance the awareness and knowledge of the medical community regarding the available options for the management of depressive disorders.