Asthma and COPD are the two common respiratory diseases with overlapping pathophysiological features, symptoms and signs, associated with considerable morbidity worldwide in different countries over the recent decades. If left untreated, both can lead to worst outcomes over time involving various body systems. Various Genome Wide Association studies, linkage and nucleotide polymorphism studies have provided sufficient data to prove that these airway abnormalities, particularly airway inflammation in both are linked to variations in genes on different chromosomes .Identification of the influence of genetic profile in Asthma and COPD provides the basis of effect of dietary factors and exercise on gene modifications. Consumption of diet rich in antioxidants, vitamins, and polyunsaturated fatty acids can lower the expression of inflammation related genes in these diseases. Similarly, exercise training reduces the inflammatory process by regulating the expression of antioxidant and inflammatory genes and up regulating the immune systems of the body.
Impact Factor
2022: 6.012
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