Stroke is the important cause of disability or death in the world, which limited therapeutics approaches are effective currently. Many researchers are trying their best to find developing new therapies for stroke. China’s long-range experience for the treatment of stroke using traditional Chinese medicines (TCMs) indicates that TCM prescriptions are not only effective, but have no or few side effects. Nowadays, TCM get wide acceptance by people because many multiple ingredients were proved reliable for the therapeutic effects. We briefly describe the mechanisms of stroke in this review, and then summarize the research that single prescription and combination prescription have performed in recent years. We hope to promote further developing of TMC in stroke therapy.