In the codification of quench, the ever-proliferating administrates the chemical or pharmacological substances only to satisfy their addiction in velociously form such as psychological, speculate medical needs and become addict of drugs. These sculptures have adroitly modified and altered the pre-existing controlled substances into new and unique derivatives that mimics similar actions as that of their parent drugs. These new drugs can be called precursors of the controlled substances for having different or unique chemical structures which conveniently circumvents the strict guidelines of the Law Enforcement System. Tryptamine are hallucinogenic drugs (mind - altering or trippy drug) which changes one’s perception about senses and reality. Tryptamine have been used increasingly over the years and cases related to serious health hazards, overdosage and death have been reported in the last decade. This study is carried out to understand TRYPTAMINE as a new aged trending designer drug.