The formation of a biofilm is regulated by various physical, chemical, and biological processes. Bacterial biofilm infections are healthcare-related, including those associated with the use of dental implants and prostheses. Oral implants associated bacterial biofilm usually caused by Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Effectiveness of many antimicrobial drugs has been lost due to the evolution of pathogenic resistance. Biofilms have the unique ability to tolerate antibiotics and immune systems. Owing to this property, biofilms develop on oral implants and lead to various diseases such as cystic fibrosis, native valve endocarditis, otitis media, periodontitis, and chronic prostatitis. Biofilms also encourage gene transfers among bacteria, which can favor the incorporation of several virulent strains. Another possible component mediated by biofilm cells is differential gene expression. Therefore, an alternative way of reducing biofilm is very essential. The anti-adherence and anti-quorum sensing compounds can be used to eradicate the bacterial biofilm by enhancing susceptibility towards the bacteria.
Impact Factor
2022: 6.012
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