The aesthetics have improved because of the high level of biomimetics of these new resin materials, which also allow for a better function within the oral cavity. The correct use of ceramic and composite materials with rigorous adhesive procedures allows sound tissue preservation because of the minimally or even noninvasive (additive) approach, which is innovative, highly esthetic, and predictable in terms of both result and long-term prognosis. This review article focuses on the material aspect of the newer generation of resin materials and summarizes recent developments in resin-composite materials for CAD/CAM applications, focusing on both commercial and experimental materials.