Diabetic retinopathy (DR), the leading cause of visual disability in diabetics in India and the world, is an important complication of diabetes mellitus (DM). Beside the retinal ascular malfunction diabetes can lead to multifaceted damage to whole of ocular tissue. Choroid needs a crucial assessment in this regard to elucidate the paradigm of functions and pathophysiology that have occurred from chronic diabetic changes. Although we
are concerned about the Diabetic Macular Edema (DME) because it is directly linked with functional visual outcome. Beside retina, Recent researches have significantly influenced our understandings on co are the modern imaging tools such as the optical coherence tomography (OCT) and its advanced modalities like Enhanced Depth Imaging(EDI) emphasised on better imaging of choroid and it is established that choroid is more vulnerable in diabetics and prone to damage before any retinal disorder like DME develops. The review highlights the choroidal microanatomy and its relates its thickness proportional to its function. It also revitalizes the understandings of diabetic changes that take place in retina choroidal interphase to bring forth the ultimate fate of irreversible damage to choroid.