Objective: To evaluate the effect of ethanolic extract of Cleome viscosa leaves on acetic induced colitis in rats.
Materials and methods: Animals were divided into six groups with six animals in each group. Group I was taken as normal control, Group II-VI , were administered 0.2ml of 10% acetic acid intrarectally, following which Group III received sulfasalazine (360mg/kg) and GroupIV, Group V, Group VI received ethanolic extract of Cleome viscosa in the doses of 100, 200, 400mg/kg respectively for 14 days. Then the animals were sacrificed and the distal colon of the different groups was dissected out and the mucosal damage was evaluated based on their weight (gms), macroscopic score and histopathological score.
Results: The results showed that there was statistically significant decrease in mucosal damage in all the three groups receiving ethanolic extract of Cleome viscosa leaves as compared to Group II, the disease control. However the mucosal damage was least in Group III, which received sulfasalazine as a standard drug for IBD.
Conclusion: Ethanolic extract of Cleome viscosa leaves has been found to reduce both microscopic as well as macroscopic damage of the colonic mucosa following acetic acid induced colitis in rats.
Impact Factor
2022: 6.012
This work is licensed under a