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The incidence of biliary tract pathologies increases as leading to an increase in the demand of therapeutic use of endoscopic retrograde cholangio- pancreatography (ERCP). This retrospective study was carried out to assess the effectiveness of therapeutic ERCP in predominantly biliary pathology. It was a prospective observational study. Patients referred for therapeutic ERCP from January2015 to December 2018 were reviewed by a preformed data sheet which included all the relevant details of the procedure. Of 273 patients audited, successful therapeutic ERCP was performed in 91.04% cases. Our study showed that ERCP was effective in the biliary disorders.