The metabolic consequences of prolonged hyperglycemia and dyslipidemia, including accelerated atherosclerosis, chronic kidney disease and blindness pose an enormous burden on patients with diabetes milletus and on the public health system. We planned a study to evaluate the effect of metformin and vitamin c combination on insulin level in streptozotocin induced diabetes in rats. Inbred adult male albino rats were obtained from the Central animal house, Madurai Medical College for the study. 24 adult male albino rats each weighing 150 to 200 grams were used in the study. Animals were divided into four groups, of six animals in each group. Animals were allowed to take standard diet (pellet feed) and tap water ad libitum. Animals in the test group 1 received Tab.Metformin200mg/kg and Tab. Vitamin C 50mg/kg for 28 days. Animals in the test group 2 received Tab. Metformin 200mg/kg and Tab. Vitamin C 100mg/kg for 28 days. Fasting blood sugar was measured for all rats on 1st, 3rd, 7th , 14th, 21st and 28th day respectively. Cardiac puncture was on 28th day for all rats to measure the insulin level. Comparison of serum insulin level showed significant increase in the standard, test 1 and test 2 groups . In this test 1 and test 2 showed better results than standard. Test 2 had better results than test 1.
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