Introduction: Demyelinating diseases characterised by inflammation and selective destruction of CNS myelin and are most common cause of non traumatic disability in young
Aim: To study clinical presentation, course, prevalence of primary and secondary demyelinating lesions and response to steroids and short term follow up
Materials And Methods: Prospective study in teaching hospital from May 2016 to September 2017 of fifty suspected male and female of age > 13 years subjected to serological and radiological tests
Results: Most common age group affected was 20-30 years, accounting for 30% of cases. 18% of cases were <20 years of age, 22% and 14% were 31-40 and 41-50 years respectively. None of the patients were > 60 years of age. 31 patients ( 62%) were females and 19 ( 38%) were males. 25 cases (50%) were transverse myelitis; 12 (24%) ADEM; 5 (10%) multiple sclerosis; 2 (4%) NMOSD and 6 cases (12%) were secondary demyelinating diseases. Paraparesis and paraplegia most common presentation ( 48% ) followed by bladder involvement (32%). Quadriparesis and quadriplegia seen in 22% ,
Sensory involvement in 6%, INO 4%, motor and optic nerve involvement 4% ,
hemiparesis in 4% and ataxia was seen in one case.
Conclusions: Demyelinating diseases of CNS are common in younger age group, females are most affected. Primary are more common than secondary .NMO
responds poorly to steroids
Impact Factor
2022: 6.012
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