Objectives: To find out the prevalence of Pemphigus in patients attending the clinical OPD of AIMSR by using Quantitative direct ELISA technique and to demonstrate the antibodies those are formed against desmoglein proteins in the patients of pemphigus. Material and methods: A study was conducted for a period of two months on 60 patients who had intra-epidermal blistering skin lesions. Direct ELISA test was done for the identification of Pemphigus vulgaris and Pemphigus foliaceus by detecting the presence of antibodies against Desmoglein proteins. In Pemphigus vulgaris antibodies against DSG 3 or both DSG 1 and DSG 3 are formed, in pemphigus foliaceus antibodies against DSG 1 are formed. Result: Out of 3757 people, who have attended OPD of AIMSR, 60 patients with intraepidermal blistering skin lesions were selected and with their consent their blood samples were tested for anti DSG antibodies. The prevalence of pemphigus came out to be 0.43 % (16) and the prevalence of pemphigus vulgaris was 0.35 % (13) and pemphigus foliaceus was 0.08 % (3). Among the 16 patients who have Pemphigus, Pemphigus vulgaris was found to be the commonest subtype accounting to 81.25% (13/16 cases) followed by a less common variant Pemphigus foliaceus accounting to 18.75% (3/16 cases). Antibodies against DSG3 were found in serum samples of 5 patients of Pemphigus vulgaris, against both DSG1 and DSG3 are found in the remaining 8 serum samples of patients of Pemphigus vulgaris and antibodies against DSG1 aloe were found in serum samples of 3 patients of Pemphigus foliaceus. Conclusion: The patients whose serum samples were positive for DSG 1 had Pemphigus foliaceus and the patients whose serum samples were positive for DSG 3 or both DSG 1 and DSG 3 had Pemphigus vulgaris. Thus, according to this data, there are 0.43% of the 3,757 patients who have visited the OPD overall who had Pemphigus.
Impact Factor
2022: 6.012
This work is licensed under a