The prevalence of hyponatremia in patients of acute coronary syndrome and its association with the patient outcome

Aims: To study the prevalence of hyponatremia in the patients admitted with Acute Coronary Syndrome (ACS) and its association without come of patient sat30 days and 90days follow up. Methods: Total 68 patients, admitted with ACS, were studied. The serum sodium levels were measured at the time of admission, at 24 hours and at the time of discharge. All the patients were followed up telephonically at day 30 and day 90 of index event. Results: Of the 68 patients, 62% were male; most common age of presentation was 41-60 years in 45.5%. Smoking and dyslipidemia were the common risk factors for ACS. Hyponatremia was noted in 29.4% patients among the study population. Patients of ACS with hyponatremia had higher pulse rate at presentation which was statistically significant (p-0.018).Among hyponatremic group 13(65%) patients and among non-hyponatremic group 33(69%) patients stayed in the hospital for 4-7days. The duration of hospital stay, readmission on follow up at Day 30 was similar in both groups. On follow up at day 90, 5(25%) of 20 patients of ACS with hyponatremia were re-admitted where as 3(6%) of total 48 patients in non-hyponatremia group were re-admitted however difference was not statistically significant. There was increased mortality among patients of ACS with hyponatremia at follow up period at 90 days than those without hyponatremia (20% vs 8%) which was statistically significantly (p-0.006). Conclusion: The patients of ACS with hyponatremia at time of hospitalization had significantly higher pulse rate at presentation and had significantly higher all cause mortality on follow up at day 90 after discharge from the hospital.