Background: Sore throat is a common postoperative complaint in patients receiving general anaesthesia requiring endotracheal intubation. Incidence ofpost operative sorethroat (POST) is 21-65%. Though it is a minor complication but valid reason for dissatisfaction and morbidity among patients. Objective: Primary objective of the study is to compare incidence & severity of POST at 4th hour in patients nebulized with ketamine and magnesium sulfate. To compare the incidence & severityof hoarseness of voice & cough. Materials and methods: After Institutional Ethics Committee approval and written informed consent, 144 patients who fulfilled the inclusion and exclusion criteria were randomly divided into two groups by sealed envelope method to receive magnesium sulfate 500mg in 4ml saline in Group M andketamine 50 mg in4ml saline nebulization in Group K 10 minutes before the start of general anaesthesia for 10 minutes. All patients received standard anaesthesia protocol. After extubation, all patients were enquired about the incidence and severity of POST, Hoarseness of voice & Cough at 0th, 2nd, 4th, 6th, 12th& 24thhours. Results: Overall incidence of POST was 25.69% Out of these 21 patients in group K (29.16%) & 16 patients in group M (22.22%) experienced POST(p=0.03). Although, Magnesium sulfate nebulization was significantly reduced incidence of POST as compared to ketamine (p=0.03), but on the basis of severity both the drugs are equally effective. (p=>0.05) In case of hoarseness of voice & cough reduced incidence & severity observed in both the groups. (p=>0.05). Conclusion: Preoperative nebulization with ketamine or magnesium sulfate is equally effective in reducing postoperative sore throat, hoarseness of voice and cough if given through nebulization ;10 minutes before induction of anaesthesia for 10 minutes.
Impact Factor
2022: 6.012
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