The present study aimed to establish the phytochemical profile of methanol, ethanol, chloroform and water extract of leaves of Dodoneae viscosa (L) Jacq and Acalypha indica L. The research study revealed the presence of alkaloids, flavonoids, steroids, terpenoids, anthraquinones, phenols, saponins, tanins, carbohydrates and oil respectively and the methanolic extract of both the plant sample contains most of the phytochemicals tested compared to other solvents. From the methanolic extract of both the plant sample crude alkaloids and crude flavonoids were extracted and their antioxidant activity were determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and H2O2 method. The methanolic extract of Dodoneae viscosa (L) Jacq was found to have higher amount of crude alkaloids content while the crude flavonoids content was more in Acalypha indica L. The antioxidant activity study revealed that the crude alkaloids of Dodoneae viscosa (L) Jacq and crude flavonoids of Acalypha indica L were found to have more free radical scavenging activity and it could explain and justify some of their uses in traditional medicine and they need further exploration for their use in modern system of medicines.